Understanding the Causes of Uterine Fibroids

While the exact cause of fibroids remains a topic of ongoing research, several factors have been identified that contribute to their development. As a leading provider of women's health services at Complete Healthcare for Women, Dr. Richard Lorenzo is dedicated to helping patients understand and manage conditions like fibroids.

Genetic Factors

Genetics play a significant role in the development of fibroids. Research has shown that fibroids tend to run in families, indicating a hereditary component. Women with a family history of fibroids are more likely to develop them. Specific genetic mutations in the cells of the uterine muscle have also been identified in some fibroids, further supporting the genetic link.

Hormonal Influences

Hormones, particularly estrogen and progesterone, are closely linked to fibroid growth. These hormones stimulate the development of the uterine lining during each menstrual cycle in preparation for pregnancy. Fibroids have been found to contain more estrogen and progesterone receptors than normal uterine muscle cells, suggesting that these hormones can promote the growth of fibroids. This explains why fibroids often grow during pregnancy, when hormone levels are elevated, and shrink after menopause when hormone levels decrease.

Growth Factors

Growth factors are substances in the body that help maintain tissues and influence cell growth. One such factor, insulin-like growth factor, has been implicated in the growth of fibroids. These growth factors can affect the behavior of cells within fibroids, promoting their development and enlargement.

Extracellular Matrix (ECM)

The extracellular matrix (ECM) is a network of proteins and other molecules that provide structural and biochemical support to cells. In fibroids, there is an increased amount of ECM compared to normal uterine muscle cells. This excess ECM makes fibroids more fibrous and can store growth factors, contributing to the abnormal growth of these tumors.

Risk Factors

Several risk factors have been associated with an increased likelihood of developing fibroids:

• Age: The risk of developing fibroids increases with age, particularly during a woman's 30s and 40s, and up to menopause. After menopause, fibroids often shrink due to the decrease in hormone levels.
• Family History: Women with a mother or sister who had fibroids are at a higher risk of developing them.
• Ethnicity: Fibroids are more common in black women than in women of other racial groups. Additionally, black women tend to develop fibroids at younger ages and are more likely to have larger and more numerous fibroids.
• Obesity: Being overweight increases the risk of fibroids. Higher levels of body fat can lead to higher levels of estrogen, which may promote fibroid growth.
• Diet: A diet high in red meat and low in green vegetables, fruit, and dairy has been linked to an increased risk of fibroids. Maintaining a balanced diet may help reduce this risk.

Managing Fibroids

At Complete Healthcare for Women, Dr. Richard Lorenzo and his team are committed to providing comprehensive care for women with fibroids. Understanding the factors that contribute to fibroid development can help in managing and treating this condition. If you have concerns about fibroids or are experiencing symptoms, such as heavy menstrual bleeding, pelvic pain, or frequent urination, it is essential to seek medical advice. Early diagnosis and appropriate management can significantly improve your quality of life.

For more information or to schedule a consultation, please contact us at Complete Healthcare for Women or call 509-392-6700. Dr. Richard Lorenzo and our dedicated team are here to support your health and well-being.

Complete Healthcare for Women - Obstetrics and Gynecology

509-392-6700

Richard Lorenzo, D.O.

Kortney Jones ARNP

Author

Richard Lorenzo, DO Dr. Lorenzo is a Fellow of the American Congress of Obstetricians and Gynecologists (ACOG) and the American College of Osteopathic Obstetricians and Gynecologists (ACOOG), reflecting his expertise in women’s health. He provides comprehensive gynecological and obstetric services, including prenatal care up to 20 weeks, infertility evaluations, and general gynecology. Dr. Lorenzo specializes in advanced surgical techniques, offering minimally invasive procedures for abnormal uterine bleeding, endometriosis, and hysterectomy, ensuring quicker recovery and minimal discomfort for his patients. He is highly trained in high-risk obstetrics and adept at performing minimally invasive hysterectomies, providing women with effective solutions tailored to their needs. At Complete Healthcare for Women in Richland, WA, Dr. Lorenzo prioritizes personalized, compassionate care, empowering women to make informed health decisions.